68 clinics ranked by DR ScoreUpdated 0 paid placements in this rankingHow we rank →
Top DR Score among weekend and evening dentists: Irvine Smile Design, 4.9★ from 892 Google reviews, open evenings until 7 PM and Saturdays until 2 PM.
Best for Saturdays: Anko Hsiao Inc, 5.0★ from 42 Google reviews, open 7 days until 6 PM.
Best for Sundays: Dr. Michael Anderson, Dentist, 1.0★ from 1 Google reviews, open 7 days until 12 AM.
Best for evenings: Mario Tai, 4.0★ from 4 Google reviews, open evenings until 12 AM and Saturdays until 3 PM.
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68 of Irvine’s 237 clinics open Saturdays, Sundays or after 6pm, as of October 2026. 68 open on Saturdays, 5 on Sundays and 10 after 6pm. 4 are open 7 days a week.
| Rank | Clinic | DR Score | Rating (reviews) | Evenings / weekends | Best for |
|---|---|---|---|---|---|
| 1 | Irvine Smile Design | 72 | 4.9★ (892) | Evenings · Sat | Top DR Score among weekend and evening dentists |
| 2 | Anko Hsiao Inc | 71 | 5.0★ (42) | Sat · Sun | Best for Saturdays |
| 3 | Irvine Children's Dentistry | 69 | 5.0★ (486) | Evenings · Sat | — |
| 4 | Dr. Michael Anderson, Dentist | 69 | 1.0★ (1) | Evenings · Sat · Sun | Best for Sundays |
| 5 | Los Angeles Dental Sedation Specialists | 68 | 5.0★ (40) | Sat · Sun | — |
| 6 | OC Dental Specialists | 67 | 4.6★ (262) | Evenings · Sat | — |
| 7 | Kim Family Orthodontics | 66 | 5.0★ (785) | Sat | — |
| 8 | Yanagi Dental Irvine - Dr. Glenn Yanagi (Centre for TMD & TMJ Pain) | 66 | 5.0★ (10) | Evenings · Sat | — |
| 9 | Tiny Teeth Children's Dentistry | 66 | 4.5★ (57) | Sat | — |
| 10 | Irvine Tooth Cafe & Orthodontics | 64 | 5.0★ (220) | Sat | — |
Posted weekly hours for the highest-ranked clinics open on weekends or after 6pm.
Mon 7 AM–7 PM · Tue 7 AM–4 PM · Wed–Thu 7 AM–7 PM · Fri 7 AM–2 PM · Sat 8 AM–2 PM · Sun closed
Evenings · Saturday
Mon 11 AM–6 PM · Tue 10:30 AM–6 PM · Wed 12 PM–5 PM · Thu–Sun 11 AM–6 PM
Saturday · Sunday
Mon–Thu 7:30 AM–6:30 PM · Fri 7:30 AM–6 PM · Sat 7:30 AM–3:30 PM · Sun closed
Evenings · Saturday
Mon 8 AM–6 PM · Tue–Wed 9 AM–6 PM · Thu 9 AM–7 PM · Fri 8 AM–6 PM · Sat 9 AM–4 PM · Sun closed
Evenings · Saturday
Mon 8:30 AM–5:30 PM · Tue 12 PM–6 PM · Wed 8:30 AM–5:30 PM · Thu 12 PM–6 PM · Fri closed · Sat 8 AM–1 PM · Sun closed
Saturday
Yanagi Dental Irvine - Dr. Glenn Yanagi (Centre for TMD & TMJ Pain)#8
Mon–Tue 9 AM–6 PM · Wed 11 AM–7 PM · Thu 9 AM–4 PM · Fri 9 AM–6 PM · Sat 9 AM–4 PM · Sun closed
Evenings · Saturday
Ordered by DR Score, a 0–100 score from 6 published factors. Scores refresh weekly.
Ranked #1 because of its Google rating and review volume: 4.9★ from 892 Google reviews, the most Google reviews in Irvine (892).
15435 Jeffrey Rd #125, Irvine, CA 92618
Ranked #2 because of its Google rating and recent reviews: 5.0★ from 42 Google reviews, about 42 reviews in the last 12 months.
18124 Culver Dr # E, Irvine, CA 92612
Ranked #3 because of its Google rating and review volume: 5.0★ from 486 Google reviews, 486 Google reviews.
16652 Von Karman Ave, Irvine, CA 92606
Ranked #4 because of its Google rating and access: 1.0★ from 1 Google review, open 7 days until 12 AM.
Ranked #5 because of its Google rating and review volume: 5.0★ from 40 Google reviews, 40 Google reviews.
15825 Laguna Canyon Rd Ste 206, Irvine, CA 92618
Ranked #6 because of its Google rating and review volume: 4.6★ from 262 Google reviews, 262 Google reviews.
15771 Rockfield Blvd Ste 100, Irvine, CA 92618
Ranked #7 because of its Google rating and review volume: 5.0★ from 785 Google reviews, 785 Google reviews.
37 Creek Rd Ste 100, Irvine, CA 92604
Ranked #8 because of its Google rating and recent reviews: 5.0★ from 10 Google reviews, 8 reviews in the last 12 months.
18 Endeavor Ste 302, Irvine, CA 92618
Ranked #9 because of its Google rating and recent reviews: 4.5★ from 57 Google reviews, about 56 reviews in the last 12 months.
18124 Culver Dr Ste B, Irvine, CA 92612
Ranked #10 because of its Google rating and review volume: 5.0★ from 220 Google reviews, 220 Google reviews.
4980 Barranca Pkwy Ste 205, Irvine, CA 92604
Ranked #11 because of its Google rating and review volume: 5.0★ from 261 Google reviews, 261 Google reviews.
250 E Yale Loop Ste C, Irvine, CA 92604
Ranked #12 because of its Google rating and review volume: 4.9★ from 76 Google reviews, 76 Google reviews.
250 E Yale Loop #202, Irvine, CA 92604
Ranked #13 because of its Google rating and review volume: 5.0★ from 353 Google reviews, 353 Google reviews.
15785 Laguna Canyon Rd Ste 240, Irvine, CA 92618
Ranked #14 because of its Google rating and review volume: 5.0★ from 73 Google reviews, 73 Google reviews.
1400 Reynolds Ave Ste 150, Irvine, CA 92614
Ranked #15 because of its Google rating and review volume: 5.0★ from 82 Google reviews, 82 Google reviews.
4902 Irvine Center Dr Ste 101, Irvine, CA 92604
Ranked #16 because of its Google rating and review volume: 4.9★ from 126 Google reviews, 126 Google reviews.
4482 Barranca Pkwy Ste. 102, Irvine, CA 92604
Ranked #17 because of its Google rating and review volume: 4.9★ from 241 Google reviews, 241 Google reviews.
14150 Culver Dr #200, Irvine, CA 92604
Ranked #18 because of its Google rating and recent reviews: 5.0★ from 17 Google reviews, 11 reviews in the last 12 months.
4605 Barranca Pkwy #200, Irvine, CA 92604
Ranked #19 because of its Google rating and review volume: 4.8★ from 52 Google reviews, 52 Google reviews.
4950 Barranca Pkwy #310, Irvine, CA 92604
Ranked #20 because of its Google rating and review volume: 4.9★ from 39 Google reviews, 39 Google reviews.
4950 Barranca Pkwy #304, Irvine, CA 92604
Ranked #21 because of its Google rating and review volume: 4.6★ from 120 Google reviews, 120 Google reviews.
4940 Irvine Blvd #107, Irvine, CA 92620
Ranked #22 because of its Google rating and recent reviews: 5.0★ from 14 Google reviews, 9 reviews in the last 12 months.
4968 Booth Cir #109, Irvine, CA 92604
Ranked #23 because of its Google rating and review volume: 5.0★ from 63 Google reviews, 63 Google reviews.
13234 Jamboree Rd, Irvine, CA 92602
Ranked #24 because of its Google rating and review volume: 4.4★ from 227 Google reviews, 227 Google reviews.
113 Waterworks Way #220, Irvine, CA 92618
Ranked #25 because of its Google rating and recent reviews: 3.4★ from 5 Google reviews, 5 reviews in the last 12 months.
#1 to #25 are shown in full above. Here are #26 to #68, in DR Score order; each links to its full profile.
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This list covers the 68 Irvine clinics that open Saturdays, Sundays or after 6pm. We scored 68 Irvine clinics on 6 factors: reputation 45%, review volume 15%, recency 10%, access 15%, services 10%, profile completeness 5%. 2 were excluded (2 duplicate listings). Data from Google listings and clinic websites, refreshed October 21, 2026.
Paid placement never changes a rank or score. Featured clinics are paid, labelled, limited to 3 and shown above the ranking, outside it.
| Factor | Weight | Computed from | In Irvine data |
|---|---|---|---|
| Reputation | 45% | Bayesian-adjusted Google star rating | Measured |
| Review volume | 15% | log10(review count) against the city maximum | Measured |
| Recency | 10% | Share of reviews in the last 12 months | Measured |
| Access | 15% | Evenings, Saturday, Sunday, same-day/emergency, accepting new patients | Measured |
| Services | 10% | Services offered out of 17 | Measured |
| Profile completeness | 5% | Named dentists, years open, languages, insurance, photos | Measured |